Protein Details: Voltage gated channel-like protein 1
Protein ID
ICDB_Pro_1224
Protein Name
Voltage gated channel-like protein 1
Gene Name
Nalcn; Vgcnl1
Organism
Mus musculus (Mouse)
Length
1738 amino acids
AlphaFoldDB
AF-Q8BXR5-F1-model_v4.pdb
Function
Voltage-gated ion channel responsible for the resting Na(+) permeability that controls neuronal excitability. NALCN channel functions as a multi-protein complex; which consists at least of NALCN; NALF1; UNC79 and UNC80. NALCN is the voltage-sensing; pore-forming subunit of the NALCN channel complex. NALCN channel complex is constitutively active and conducts monovalent cations but is blocked by physiological concentrations of extracellular divalent cations (By similarity). In addition to its role in regulating neuronal excitability; is required for normal respiratory rhythm; systemic osmoregulation by controlling the serum sodium concentration and in the regulation of the intestinal pace-making activity in the interstitial cells of Cajal . Plays a critical role in both maintenance of spontaneous firing of substantia nigra pars reticulata (SNr) neurons and physiological modulation of SNr neuron excitability . NALCN channel is also activated by neuropeptides such as neurotensin and substance P (SP) through a SRC family kinases-dependent pathway . In addition; NALCN activity is enhanced/modulated by several GPCRs; such as CHRM3 .
Sequence
PDB Structures
Ligand Binding
Binding Site
Disease
Location
Widely expressed in the brain and spinal cord neurons (PubMed:17448995). Expressed also in pancreatic islet cells (PubMed:19575010).